Intravascular Laser Irradiation Of Blood Research Articles

Photobiomodulation for Blood Pressure and Heart Rate Reduction in Mastectomized Women on Hormone Blockers: A Randomized Controlled Trial.

Objective: To assess the impact of intravascular laser irradiation of blood (ILIB) on the primitive carotid artery (PCA) hemodynamic variables, specifically blood pressure (BP) and heart rate (HR), in mastectomized patients undergoing hormone blocker treatments. Materials and methods: This study is a controlled, experimental, and randomized clinical trial. Patients were allocated into two groups: the experimental group (G1)-patients who received ILIB therapy using a 660 nm laser targeted at the PCA, and the control group (G2)-patients who did not receive ILIB therapy. Clinical research was conducted weekly, with measurements of systolic blood pressure (SBP), diastolic blood pressure (DBP), and HR. The Mann-Whitney U test for independent samples was used, with a significance level of α = 0.05. Results: Systemic photobiomodulation on the PCA did not demonstrate a statistically significant difference in relation to SBP and DBP. However, for HR, the p-value was <0.05, indicating a significant difference between G1 and G2. The initial mean p > decreased from 142.3 to 116.4 mmHg in G1, and from 130.4 to 119.8 mmHg in G2. The DBP varied from 78.8 to 72.8 mmHg in G1, and from 79.1 to 74.2 mmHg in G2. A statistically significant difference was observed in HR, decreasing from 81.3 to 62.06 bpm in G1, and changing minimally from 74.1 to 75.1 bpm in G2. A considerable reduction was present in the timing of application. Conclusions: ILIB therapy applied to the PCA induces a reduction in BP and, more notably, HR in mastectomized women using the tamoxifen or aromatase inhibitors.

Influence of Intravascular Laser Irradiation of Blood (ILIB) on inflammatory cytokines and nitric oxide in vivo: a systematic review.

The use of Intravascular Laser Irradiation of Blood (ILIB) as a treatment or adjunct tool has been used around the world since the 1980s. So that more professionals can deliver benefits to their patients in different areas of health, it is necessary to understand in depth the mechanisms of laser action at the molecular level, for correct indication and success in the treatment.To analyze works that evaluated the influence of ILIB on inflammatory cytokines and nitric oxide (NO) in animals and humans. The literature search was carried out between February and April 2023 in Pubmed, Medline, Web of Science, SciELO, Lilacs database. The risk of bias was assessed using the bias table where the authors performed the analyzes of all articles with the risk of bias domains. The methodology was defined following the PRISMA guidelines (Preferred Systematic Reviews and MetaAnalysis Report). The search retrieved 135 possibly relevant articles. After removing duplicates, according to the eligibility criteria, evaluation of titles and review of abstracts, in the end, 6 articles were included.An increase in anti-inflammatory cytokines, a decrease in pro-inflammatory cytokines and an increase in NO can be observed. The wavelengths used ranged from 660 to 808nm when using a low intensity laser and when using a VIP light source 480-3400nm, they also differed in terms of the light emission pattern.ILIB may be a complementary treatment option for patients who have comorbidities that lead to systemic inflammation.

Intravascular laser irradiation of blood as novel migraine treatment: an observational study

BackgroundMigraine is one of four major chronic diseases that cause disability. Decreases in regional cerebral blood flow (rCBF) occur during migraine attacks. Laser therapy is extensively employed in treating other vascular diseases; nevertheless, its effectiveness in migraine management remains largely unknown. Therefore, we evaluated the effect of low-level intravascular laser irradiation of blood (ILIB) therapy in patients with migraine.MethodsWe performed an observational case–control study in 24 patients suffering from migraine. Patients were divided into an ILIB treatment group and a traditional rehabilitation group. This study performed clinical assessments and single-photon emission computed tomography (SPECT) prior to and after the treatment and 1 month later. Changes in rCBF-SPECT between groups and between timepoints were compared to clinical outcomes.ResultsNine patients undergoing rehabilitation and fifteen patients undergoing ILIB were studied from baseline to 1 month follow-up. The ILIB group, visual analog scale for pain (P = 0.001), Montreal Cognitive Assessment (P = 0.003), and Athens Insomnia Scale (P < 0.001) symptom scores significantly improved after treatment. SPECT imaging showed a 1.27 ± 0.27 fold increase in rCBF after ILIB treatment, and no significant differences in the rehabilitation group.ConclusionsLow-level ILIB therapy is associated with better clinical and vascular outcomes, and may be a feasible treatment option for migraine. Although our sample size was small, our data provide a starting point for migraine laser therapy research.

Effects of Intravascular Photobiomodulation on Insomnia, Muscle Soreness, and Biochemistry Profiles: An Eight-Year Retrospective Cohort.

Although cognitive-behavioral therapy is the first-line treatment for insomnia, pharmacotherapy is often prescribed to treat insomnia and related symptoms. In addition, muscle relaxants are commonly prescribed to alleviate muscle soreness when the pain is unbearable. However, pharmacotherapy can lead to numerous side effects. The non-drug strategy intravascular laser irradiation of blood (iPBM) has been advocated to improve pain, wound healing, blood circulation, and blood cell function to relieve insomnia and muscle soreness symptoms. Therefore, we assessed whether iPBM improves blood parameters and compared drug use before and after iPBM therapy. Consecutive patients who received iPBM therapy between January 2013 and August 2021 were reviewed. The associations between laboratory data, pharmacotherapies, and iPBM therapy were retrospectively analyzed. We compared patient characteristics, blood parameters, and drug use within the three months before the first treatment and the three months after the last treatment. We also compared the changes before and after treatment in patients who received ≥10 or 1-9 iPBM treatments. We assessed 183 eligible patients who received iPBM treatment. Of them, 18 patients reported insomnia disturbance, and 128 patients reported pain in any part of their body. After the treatment, HGB and HCT significantly increased after treatment in both the ≥10 and 1-9 iPBM treatment groups (HGB p < 0.001 and p = 0.046; HCT p < 0.001 and p = 0.029, respectively). Pharmacotherapy analysis revealed no significant differences in drug use before and after treatment, though drug use tended to decrease after iPBM. iPBM therapy is an efficient, beneficial, and feasible treatment that increases HGB and HCT. While the results of this study do not support the suggestion that iPBM reduces drug use, further larger studies using symptom scales are needed to confirm the changes in insomnia and muscle soreness after iPBM treatment.

Intravascular laser irradiation of blood (ILIB) used to treat lung diseases: a short critical review.

Intravascular laser irradiation of blood (ILIB) was developed to treat cardiovascular diseases due to its rheological effects. In its original form, ILIB was applied by an intravenous optical fiber, restricting its application. However, this technique was modified to non-invasive irradiation through the radial artery, now called vascular photobiomodulation (VPBM). Many studies have used both, ILIB and VPBM, to treat lung diseases. It is well established that lung diseases affect more than 300 million people worldwide with high morbidity and mortality rates. In this short critical review, we discuss the potential benefits of photobiomodulation to treat lung diseases using these two approaches. The search was performed in the electronic database of MEDLINE (Medical Literature Analysis and Retrieval System Online) via PubMed. The data search was carried out from 1991 to 2017. We selected a total of 10 clinical studies using either ILIB or VPBM, in addition to 2 experimental studies in animals. The respiratory diseases treated in these studies included bronchitis, asthma, pneumonia, and tuberculosis. The results showed overall beneficial effects on lung diseases, characterized by a reduction in the inflammatory cascade and antioxidant effects, improvement of hemodynamic parameters, the efficiency of gas exchange, and reduction of hospitalization periods. In conclusion, all studies showed promising effects of ILIB in both animal and human studies. The studies did not discuss any disadvantages or contraindications. However, further studies are needed in order to understand the dosimetry, and the literature is lacking in randomized, controlled clinical trials. Thus, this review highlights the need for additional studies using this approach.

Intravascular laser irradiation of blood in the treatment of fibromylagia: integrative literature review

Background: Low-Intensity Laser Therapy (LLLT), applied to trigger points, can be used as adjuvant therapy in the treatment of Fibromyalgia. However, in Brazil, the application of intravascular technique applied transdermally on the radial artery has been widespread as a promising modality of treatment. But as far as we know, its effects are still not fully understood in the treatment of this pathology. Objective: To investigate the scientific evidence for the use of intravascular laser blood irradiation (ILIB) in the treatment of fibromyalgia. Method: this is an integrative literature review (PROSPERO registration CRD42021236744) to identify clinical studies that demonstrate the effect of ILIB on fibromyalgia, without time or language restrictions. Searches were performed and published in 4 databases (PubMed, PeDRO, EMBASE, and Scielo), by 2 independent reviewers, using the descriptors “fibromyalgia” associated with “laser” or “low-level light therapy” or “laser irradiation” ” or “photobiomodulation” or “phototherapy” or “blood irradiation” or “modified ILIB” or “intradermal ILIB”. Results: 3,050 articles were identified. Of these, only 62 met the eligibility criteria, and 32 were duplicates. Thus, 30 studies were rich, but none of them correspond to a clinical study using ILIB in fibromyalgia. However, two secondary sources and four secondary cases were found, with low methodological rigor, but which presented positive positive results, as well as antioxidant and circulatory systemic effects. No substantiated evidence of completion of IB clinical trials in fibromyalgia was identified for their clinical substantiation.    

Evaluation of photobiomodulation as a pain prevention alternative in orthodontic movement after installation of orthodontic appliances: randomized clinical study

Introduction: Photobiomodulation is a promising technique for pain management, whether local and/or systemic, due to the beneficial effects generated by the application of laser. Objective: To evaluate the clinical application of intravascular laser irradiation of blood (ILIB) and photobiomodulation (PBM-T), as a predictor of improvements and/or pain prevention and compare its effectiveness when combinated or not. Methods: The present study was carried out with 71 patients, selected according to the inclusion and exclusion criteria and randomly divided into 4 groups regarding the laser application procedure, namely: control group, PBMT, ILIB and PBMT + LIB. All patients were instructed and should fill out questionnaires regarding quality of life parameters and VAS scales and the Facial Pain Scale (EFD) after the procedure. Results: It was observed in the initial evaluation, a difference (p&lt;0.001) regarding the limitation of food and pain when chewing, "sensitivity" in the experimental groups, as well as the values obtained for the variables EFD and VAS were different from the control group. . The statistical difference in the experimental groups was maintained in the evaluation time of 24h, (p&lt;0.001) regarding the variables, between the groups. And in the evaluation time of 3 days, lower values were observed, being similar between the groups only in the evaluation of 7 days. Conclusion: It can be concluded that photobiomodulation is an effective option for pain prevention. Regarding their use, when compared in isolation, PBMT and ILIB present similar results, and when associated, the techniques have a greater analgesic and pain prevention effect when compared to the other groups.

Clinical applications of ILIB technique in Dentistry – State of Art

Intravascular Laser Irradiation of Blood (ILIB) represents a systemic laser photobiomodulation, where irradiation of a given artery is recommended through the use of laser light with different wavelengths. The technique developed in the 1970s, in the former Soviet Union. The present narrative review aimed to describe current aspects of ILIB therapy and its indications in different areas of health, especially in Dentistry. For the selection, searches were carried out in the PubMed, Google Scholar, Scielo and Cochrane databases, from October 2020 to January 2021. Scientific articles were selected in Portuguese and English, which had the full text available and which were published between 2015 and 2020. Some manuscripts were added for contextualization, totaling 53 studies. It was observed that the systemic effect of ILIB is achieved by irradiating the blood circulation. Increased cellular metabolism, increased production of nitric oxide and stimulated the action of the enzyme CuZn Superoxide Dismutase have been reported, and also had a documented analgesic and anti-inflammatory effect. Studies suggest that ILIB has been indicated in different areas of health and can be applied in the prevention and treatment of systemic and local, chronic and acute conditions. In dentistry, the technique was most suitable for the treatment of inflammatory conditions, such as periodontitis, mucositis, postoperative surgeries and orofacial pain. Thus, the effects of ILIB suggest its use in dental practice. However, further studies are needed, such as randomized clinical trials, to validate the use of ILIB.

Optimization of the dental implant with the use of ILIB: major considerations

Introduction: In the context of implantology and osseointegration for the stabilization of dental implants, the use of ILIB (Intravascular Laser Irradiation of Blood) to stimulate tissues, cells, and molecules at the systemic level stands out. In this sense, ILIB can be used with postoperative applications in the osseointegration and stability of dental implants. Objective: Conducted a concise systematic review of the main findings of using the ILIB to improve dental implant practices. Methods: The research was carried out from May 2021 to June 2021 and developed based on Scopus, PubMed, Science Direct, Scielo, and Google Scholar, following the Systematic Review-PRISMA rules. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results: A total of 58 studies were analyzed, with only 10 medium and high-quality studies selected, according to GRADE rules, and with risks of bias that do not compromise scientific development. After analyzing the major studies, it was analyzed that, with the use of ILIB, several bone regeneration factors can be promoted and optimized for implant dentistry. Other authors have shown that ILIB therapy has oral sterilization properties, facilitating tissue healing after surgical procedures and the osseointegration process for placement of stable implants. Despite this, low-intensity laser irradiation may have limitations, as it requires specific dosimetry and few published studies on the use of ILIB in Dentistry. Conclusion: Literary findings point to the safety and efficacy of ILIB in dental implant treatments. The ILIB power is included as an eligibility criterion equal to other low power lasers. Furthermore, ILIB enables local and systemic treatment, optimizing the benefits of its use by dentists, mainly to improve the stabilization of osseointegrated implants and prevent or eliminate contamination.

Clinical Evaluation of Intravascular Blood Irradiation with Laser, Photobiomodulation, and Photodynamic Therapy in Cancer Patients with Mucositis.

Objective: To assess the clinical application of intravascular laser irradiation of blood (ILIB), photodynamic therapy (PDT), and photobiomodulation therapy (PBM-T) in mucositis in cancer patients. Background: PBM-T and PDT are used for the management of oral mucositis (OM) and there are no studies associating intravascular laser irradiation of blood (ILIB) for this purpose. Materials and methods: Thirty-six patients were allocated by convenience into three groups according to the established therapy: PDT+PBM-T (n = 10); PDT+PBM-T+ILIB (n = 10), and ILIB (n = 16). PDT was performed with the photosensitizer curcumin and irradiation of the oral cavity with blue light-emitting diode (LED) (power 1200 mW and wavelength 468 nm). PBM-T was performed using low-intensity laser (power 100 mW, wavelength 660 nm, and spot energy 1 J) at 26 points of the oral cavity. ILIB was applied with a bracelet on the radial artery using the low-intensity laser (100 mW of power, 660 nm wavelength, and 30 J of total energy). All therapies were performed weekly for 5 weeks. The results of the OM degrees were analyzed using the Wilcoxon test. Results: There was a significant reduction in the degrees of OM after treatment with PDT+PBM-T (p = 0.0117), PDT+PBM-T+ILIB (p = 0.0277), and ILIB (p = 0.0277). Conclusions: It was concluded that ILIB, PDT, and PBM-T reduced the severity of mucositis and prevented its onset. Clinical Trial Registration number: RBR-54XS25.

Intravenous Laser Therapy in Patients With Acute Kidney Injury: A Randomized Clinical Trial.

Introduction: Although intravascular laser irradiation of blood (ILIB) is deemed an innocuous and useful technique for laser therapy, particularly when systemic effects are required, no study, to our knowledge, has been conducted on the effectiveness and innocuousness of ILIB in treating acute kidney injury (AKI). Objective: This study aimed to assess the feasibility and outcomes of ILIB in the management of patients with AKI and comparing them with the Sham-laser group. Materials and Methods: Twenty-six patients with intra-renal AKI (24-95 years old) at Tajrish Hospitals were evaluated for enrollment eligibility in this clinical trial study. This study was conducted at the nephrology department of Shahid Beheshti University of Medical Science, Tehran, Iran, between 2018 and 2019. Based on the treatment method, the patients' assignment to two groups (ILIB or Sham-laser) was randomly done. Demographic characteristics, need for dialysis, hemoglobin and serum biochemistry changes, serum and urine neutrophil gelatinase-associated lipocalin (NGAL) changes, laser complications, and the hospitalization period were recorded. Results: In terms of the baseline characteristics and biochemistry serum level, no differences were seen between the two groups. All post-treatment parameters, except the hemoglobin value, significantly improved in both groups. Urine NGAL and serum NGAL show declines from the baseline in both groups; however, the reduction slope of these parameters occurred faster in the laser group in a statistically significant manner. Conclusion: A decline in NGAL levels in the laser group during the treatment may suggest that the ILIB can help patients with AKI recover better.

Effectiveness of blood irradiation by modified intravenous laser (ILIB) on the clinical parameters of fibromyalgia

Pain control remains an urgent task. If the goal is to achieve permanent pain relief and not temporarily mask the pain (masking the pathology), then that goal can only be achieved by treating the pain with physiotherapeutic methods, the most universal and effective of them is low-level laser therapy intensity (LLLT). Treatment methods vary fundamentally in the case of neuropathic pain (nonspecific, primary), which includes pain with trigger point (PT) and nociceptive (specific, secondary) pain, which includes all types of pain resulting from trauma, inflammation, etc. When treating patients with fibromyalgia (FM), which is a chronic condition with high worldwide prevalence, auxiliary therapies have been indicated for the treatment of fibromyalgia including low-level laser. Currently, the low intensity laser has been attached to a bracelet over the radial artery, in order to irradiate blood cells, using a technique called modified ILIB (Intravascular Laser Irradiation of Blood), with improved control of fibromyalgia, of chronic inflammatory processes. This study evaluated the effectiveness of the modified ILIB in improving the clinical parameters of fibromyalgia used to treat a patient who had chronic pain for 20 years, who received conventional treatment associated with two laser applications using the modified ILIB technique.

Laser acupuncture and intravascular laser irradiation of blood for management of pediatric dental anxiety.

The aim of this study was to assess the effectiveness of laser acupuncture and intravascular laser irradiation of blood (ILIB) for managing anxiety in pediatric dentistry. Eighty-four children recruited at a university dental clinic were randomly assigned to three groups: the Sham group (n = 27) underwent sham laser irradiation of three acupuncture points, the ILIB group (n = 25) underwent 10 min of ILIB, and the laser acupuncture group (LAC, n = 32) underwent 40 s of laser acupuncture over points VG20 (Baihui), PC6 (Neiguan), and the Oppression Point. The results suggest that ILIB and laser acupuncture are feasible alternatives for managing dental anxiety in children.

ILIB (intravascular laser irradiation of blood) as an adjuvant therapy in the treatment of patients with chronic systemic diseases-an integrative literature review.

To perform an integrative review of the literature on the effectiveness of intravascular laser irradiation of blood (ILIB) as an adjunct therapy in the treatment of chronic systemic diseases. This is an integrative literature review that included non-randomized and randomized controlled clinical trials that specifically evaluated the therapeutic effect of ILIB on chronic systemic diseases, without restriction of time, and written in English. The Medical Publications (PubMed)/MEDLINE database was used. MeSH (Medical Subject Headings) was used to select search descriptors with the Boolean operators "AND/OR." After applying the inclusion and exclusion criteria, 13 articles were selected. Coronary diseases were the most prevalent, followed by type 2 diabetes mellitus, with the coronary artery being the most widely used access route for ILIB application. Despite the varied parameters and protocols for using this kind of therapy, all studies have shown satisfactory results in the patients' clinical condition. ILIB proved to be effective in all organic systems, showing some positive result. However, studies on the effect of this therapy on various diseases are still scarce in the literature, and there is a need for more well-designed clinical trials to better understand the role of ILIB in various systemic diseases.

Efficiency of a low-intensity laser in the treatment of genital herpes infections

90 women at the age of 30,9±0,4 years with clinical laboratory signs of herpetic defeat of urogenital system took part in research lasting 12 months. Therapy included a preparation Valaciclovir on 500 mg, complex therapy was carried out with use of intra vascular laser radiation of blood (wavelength of 365 nm, power of the radiation of 2 mW, an influence exposition the laser of 8 min, the number of sessions 15) along with application of a preparation Valaciclovir. Results of the study indicate a positive clinical dynamics and immunomodulatory action of intravascular laser irradiation of blood that can be recommended as a method of complex treatment of herpetic lesions of the reproductive system.

Effects of Intravascular Laser Irradiation of Blood on Cognitive Function in a Stroke Survivor with Hyperhomocysteinemia: Dual Recuperations in Thalamus and Serum Homocysteine

Stroke is a major public health issue worldwide because of the high risk of unavoidable disability leading to a noteworthy burden of the patients themselves, the families and the society [1].

Benefits of intravascular laser Irradiation of Blood on Motor and Sensory Recovery Viewing from Brain Function Images: Portrait of a Case with Chronic Sjögren’s Syndrome, Transverse Myelitis, and Guillain-Barré Syndrome

Benefits of intravascular laser Irradiation of Blood on Motor and Sensory Recovery Viewing from Brain Function Images: Portrait of a Case with Chronic Sjögren’s Syndrome, Transverse Myelitis, and Guillain-Barré Syndrome

The Photobiomodulatory Therapy and ILIB in the Repair of Encephalic Cisterns and Progressive Cognitive Restoration in a Patient with Traumatic Brain Injury

This case study aims to present the process of neuropsychological rehabilitation of a patient during the acute post-trauma period, and incisive results, through the complementary (complementary) intervention of photobiomodulatory laser therapy in muscle areas of the craniofacial and photo-parenteral region by ILIB (Intravascular Laser Irradiation of Blood). These procedures contributed in a short period of time to the neuropsychological rehabilitation of this patient who had suffered severe cranioencephalic trauma and evolved with cognitive and behavioral alterations that had a significant impact on their autonomy.

[The application of intravascular laser irradiation of blood for the correction of the immune disturbances in patients presenting with chronic endometritis].

The study included 30 women of the reproductive age with the verified diagnosis of chronic endometritis at the stage of partial remission. The patients were divided into two groups. The patients of group 1 (control) were treated by pharmacotherapy alone while those in the main group (group 2) were given standard therapy supplemented by intravascular laser irradiation of blood in the form of daily 25 min sessions during a 7 day period with the use of the «Mulatto» device having the output power of 2 MW at a wavelength of 0.63 microns. In addition, the third group of comparison was formed to which age-matched healthy women were recruited. The levels of cytokines, components of the complement, and immunoglobulins were determined in blood plasma, vaginal and cervical washouts using solid-phase enzyme immunoassay. The more reliable correction of the immune disturbances was achieved with the use of low-intensive laser irradiation of blood in comparison with medicamental therapy alone as appears from the analysis of the indicators of the immune status at the systemic and local levels (anti-inflammatory and regulatory cytokines, components and regulators of the system of complement, immunoglobulins). Supplementation of the standard treatment of chronic endometritis by a course of intravascular low-intensive laser irradiation of blood allows to increase its effectiveness and thereby improve the quality of life of the patients.

Effects of Intravascular Laser Irradiation of Blood in Mitochondria Dysfunction and Oxidative Stress in Adults with Chronic Spinal Cord Injury

This study investigated the clinical effects of intravascular laser irradiation of blood (ILIB) therapy on oxidative stress and mitochondrial dysfunction in subjects with chronic spinal cord injury (SCI) resulting from trauma. Little is known about how ILIB may generate antioxidant defenses in humans, and there is still a lack of randomized, sham-control studies to indicate its influence on different metabolic pathways. Twenty-four chronic SCI subjects (assigned to a sham and a study group), and 12 normal subjects were recruited. The study group underwent 1 h daily of ILIB for 15 days over 3 weeks. The sham group underwent ILIB with no laser power. Baseline measurements established higher oxidative stress and mitochondrial dysfunction in the SCI subjects than in the normal subjects. At day 15 of therapy, the study group revealed a significantly higher mitochondrial DNA (mtDNA) copy number, white blood cell adenosine triphosphate (WBC ATP) synthesis, and total antioxidant capacity (TAC) with significantly reduced malondialdehyde (MDA), than did the sham group. The study group intragroup comparison revealed significantly increased mtDNA copy numbers, WBC ATP synthesis, and TAC, with significantly reduced MDA, compared with its baseline measurements. The sham group intragroup comparisons demonstrated no statistical differences. Low-density lipoprotein (LDL) in the study group was significantly reduced at days 10 and 15, with significantly higher high-density lipoprotein (HDL) at day 45. Our study results contribute to the knowledge about the effectiveness of ILIB in alleviating oxidative stress and mitochondrial dysfunction in chronic SCI patients.